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2021 March Madness Betting Guide

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2021 March Madness Betting Guide

After a long season of COVID protocols, a wild week of conference tournaments, and an eventful Selection Sunday, we finally have March Madness again. Here at The Odds Factory, we’re ready to celebrate the only way that we know how – by taking our hard-earned stimulus check and putting it in the hands of the 19-year-old Fortnite addicts known as college basketball players. If you’re anything like us, you’re prepared to do the same.

Luckily for you, The Odds Factory is here for you all tournament with the best picks, sportsbook promotions, and how-to-guides to make you a better bettor (say that ten times fast) this tournament.

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How to Bet Each Region

We break down each of the regions and help you pick Winners, Dark Horses, and potential Cinderella teams to win big on.

Smart Money Picks For March Madness 2021

Let’s cut the bullshit and get to what you really want to know – what should I be betting on? Our experts weigh in with their smart money picks for each round of action.

March Madness 2021 First Round Picks:

TomBox Algorithm Picks For Play-In Games:

  1. UCLA Bruins @ Michigan State Spartans: Michigan State ML (-135)
  2. Appalachian State Mountaineers @ Norfolk State Spartans: Norfolk State +3.5 (-109)
  3. Drake Bulldogs @ Wichita State Shockers: Drake -2.5 (+100)
  4. Drake Bulldogs @ Wichita State Shockers: Under 141 (-115)
  5. Texas Southern Tigers @ Mount St. Mary’s Mountaineers: Over 131 (-125)

TomBox Algorithm Picks For Friday 3/19/2021:

  1. Winthrop Eagles @ Villanova Wildcats: Villanova ML (-275)
  2. Rutgers Scarlet Knights @ Clemson Tigers: Clemson ML (+120)
  3. Rutgers Scarlet Knights @ Clemson Tigers: Clemson +2 (-105)
  4. Wisconsin Badgers @ North Carolina Tar Heels: North Carolina -1.5 (-109)
  5. Morehead State Eagles @ West Virginia Mountaineers: Morehead State +13 (-109)
  6. Cleveland State Vikings @ Houston Cougars: Under 134 (-103)
  7. North Texas Mean Green @ Purdue Boilermakers: Over 125.5 (+108)

TomBox Algorithm Picks For Saturday 3/20/2021:

  1. UC Santa Barbara Gauchos @ Creighton Bluejays: Creighton ML (-286)
  2. Ohio Bobcats @ Virginia Cavaliers: Virginia ML (-295)
  3. VCU Rams @ Oregon Ducks: VCU +5.5 (-110)
  4. Missouri Tigers @ Oklahoma Sooners: Missouri -0.5 (-110)
  5. Grand Canyon Antelopes @ Iowa Hawkeyes: Iowa -14.5 (+110)
  6. UC Santa Barbara Gauchos @ Creighton Bluejays: Over 138 (-112)
  7. Iona Gaels @ Alabama Crimson Tide: Over 147.5 (+100)

West Region:

  1. VCU Rams @ Oregon Ducks: VCU +5.5 (-109)
  2. Missouri Tigers @ Oklahoma Sooners: Over 141 (-108)
  3. UC Santa Barbara Gauchos @ Creighton Bluejays: UC Santa Barbara +6.5 (+115)

Midwest Region:

  1. Liberty Flames @ Oklahoma State Cowboys: Over 141.5 (-110)
  2. Syracuse Orange @ San Diego State Aztecs: Syracuse +3 (-110)
  3. Oregon State Beavers vs. Tennessee Volunteers: Oregon State +7.5 (-110)

South Region:

  1. Colgate Raiders @ Arkansas Razorbacks: Colgate Raiders +9.5 (-127)
  2. North Texas Mean Green vs. Purdue Boilermakers: North Texas +7.5 (-103)
  3. Hartford Hawks @ Baylor Bears: Over 140.5 (-110)

East Region:

  1. St. Bonaventure Bonnies @ LSU Tigers: St. Bonaventure +1.5 (-110)
  2. UNC Greensboro Spartans @ Florida State Seminoles: Over 145 (-110)
  3. Georgetown Hoyas @ Colorado Buffaloes: Georgetown ML (+180)

March Madness 2021 Second Round Picks:

Smart Money Picks For Sunday 3/21/2021:

  1. Rutgers Scarlet Knights @ Houston Cougars: Houston -7.5 (-105)
  2. North Texas Mean Green @ Villanova Wildcats: Villanova -5 (-132)

TomBox Algorithm Picks For Sunday 3/21/2021:

  1. Rutgers Scarlet Knights @ Houston Cougars: Houston ML (-350)
  2. Wisconsin Badgers @ Baylor Bears: Baylor ML (-286)
  3. North Texas Mean Green @ Villanova Wildcats: North Texas +6.5 (-115)
  4. Syracuse Orange @ West Virginia Mountaineers: Syracuse +3.5 (+105)
  5. North Texas Mean Green @ Villanova Wildcats: Under 127.5 (-112)
  6. Texas Tech Red Raiders @ Arkansas Razorbacks: Over 140.5 (-109)

TomBox Algorithm Picks For Monday 3/22/2021:

  1. LSU Tigers @ Michigan Wolverines: Michigan ML (-196)
  2. Ohio Bobcats @ Creighton Bluejays: Creighton ML (-240)
  3. Oklahoma Sooners @ Gonzaga Bulldogs: Gonzaga -14 (-137)
  4. Colorado Buffaloes @ Florida State Seminoles: Florida State -1.5 (-105)
  5. Maryland Terrapins @ Alabama Crimson Tide: Over 138 (-110)
  6. LSU Tigers @ Michigan Wolverines: Over 148 (+105)

Smart Money Picks For Monday 3/22/2021:

  1. Ohio Bobcats @ Creighton Bluejays: Ohio +5.5 (-109)
  2. Maryland Terrapins @ Alabama Crimson Tide: Under 138.5 (-109)
  3. USC Trojans @ Kansas Jayhawks: Kansas ML (-105)

Recap of the First Two Rounds

Sweet 16:

March Madness Sweet 16 Preview: Picks, Storylines, and Key Matchups for the Weekend:

  1. Oregon State Beavers @ Loyola Ramblers: Loyola -7 (-109)
  2. UCLA Bruins @ Alabama Crimson Tide: Alabama -6.5 (-115)

Easy Money Promotions For This Weekend of NCAA Tournament Action

TomBox Algorithm Picks For Saturday 3/27/2021:

  1. Oregon State Beavers @ Loyola Ramblers: Loyola ML (-286)
  2. Villanova Wildcats @ Baylor Bears: Baylor ML (-295)
  3. Syracuse Orange @ Houston Cougars: Syracuse +6.5 (-110)
  4. Villanova Wildcats @ Baylor Bears: Villanova +7.5 (-109)
  5. Villanova Wildcats @ Baylor Bears: Under 140.5 (+110)
  6. Oral Roberts Golden Eagles @ Arkansas Razorbacks: Over 159 (+120)

Smart Money Picks For Saturday 3/27/2021:

  1. Oral Roberts Golden Eagles @ Arkansas Razorbacks: Oral Roberts +11.5 (-109)
  2. Oregon State Beavers @ Loyola Ramblers: Loyola -7 (-109)

TomBox Algorithm Picks For Sunday 3/28/2021:

  1. UCLA Bruins @ Alabama Crimson Tide: Alabama ML (-300)
  2. Oregon Ducks @ USC Trojans: USC ML (-139)
  3. Creighton Bluejays @ Gonzaga Bulldogs: Gonzaga -13 (-110)
  4. Florida State Seminoles @ Michigan Wolverines: Florida State +2.5 (-120)
  5. Creighton Bluejays @ Gonzaga Bulldogs: Over 158 (-110)
  6. Oregon Ducks @ USC Trojans: Over 138 (-110)

Elite 8:

Smart Money Picks For Monday 3/29/2021:

  1. Oregon State Beavers @ Houston Cougars: Under 129 (-105)
  2. Arkansas Razorbacks @ Baylor Bears: Arkansas +8 (-109)

Smart Money Picks For Tuesday 3/30/2021:

  1. USC Trojans @ Gonzaga Bulldogs: USC +8.5 (+100)
  2. UCLA Bruins @ Michigan Wolverines: UCLA +6.5 (-103)

TomBox Algorithm Picks For Tuesday 3/30/2021:

  1. USC Trojans @ Gonzaga Bulldogs: Gonzaga ML (-435)
  2. UCLA Bruins @ Michigan Wolverines: Michigan -7 (+100)
  3. USC Trojans @ Gonzaga Bulldogs: Over 153 (+105)

Final 4:

2021 Men's Final Four Preview: Can Gonzaga Complete a Perfect Season?

Smart Money Picks For Saturday 4/3/2021:

  1. Houston Cougars @ Baylor Bears: Houston +5 (+100)
  2. UCLA Bruins @ Gonzaga Bulldogs: Under 145.5 (+105)

TomBox Algorithm Picks For the 2021 NCAA Final Four:

  1. Houston Cougars @ Baylor Bears: Baylor ML (-225)
  2. UCLA Bruins @ Gonzaga Bulldogs: Gonzaga -14.5 (-105)
  3. Houston Cougars @ Baylor Bears: Under 134 (+105)

National Championship:

Smart Money Picks For the NCAA Men's National Championship:

  1. Baylor Bears @ Gonzaga Bulldogs: Gonzaga -4.5 (-105)

TomBox Picks For the 2021 NCAA Men’s National Championship:

  1. Gonzaga Bulldogs vs. Baylor Bears: Gonzaga ML (-200)
  2. Gonzaga Bulldogs vs. Baylor Bears: Gonzaga -4.5 (-105)
  3. Baylor Bears @ Gonzaga Bulldogs: Under 159.5 (-109)

Betting Tips

Our degenerate experts are here with in-depth betting guides to help you hone your strategies for this tournament.

For more gambling knowledge, check out our Gambling 101 section.

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